Research Articles
Improving fMRI Test-Retest Reliability: A Comprehensive Guide for Biomarker Development and Clinical Translation
This article provides a comprehensive examination of test-retest reliability in functional magnetic resonance imaging (fMRI) for researchers and drug development professionals. Converging evidence indicates poor to moderate reliability for common fMRI measures, with meta-analyses reporting mean intraclass correlation coefficients (ICCs) of 0.397 for task-based activation and 0.29 for edge-level functional connectivity. We explore foundational concepts of reliability measurement, methodological factors influencing consistency, optimization strategies for improving reliability, and validation approaches across different contexts. The content synthesizes recent evidence on how analytical decisions, acquisition parameters, and processing pipelines impact reliability, providing practical guidance for enhancing fMRI's utility in clinical trials and biomarker development.
Therapeutic Delivery in 2025: How Science is Rewriting the Rules of Medicine
Explore the latest breakthroughs in therapeutic delivery technologies in May 2025, from nanoscale carriers to intelligent implantable devices revolutionizing medicine.
The Rhythm of Recovery: How Music Technology is Revolutionizing Stroke Rehabilitation
Exploring how Rhythmic Auditory Stimulation combined with intelligent technologies is transforming post-stroke recovery through enhanced neuroplasticity and personalized rehabilitation.
Beauty in the Shadow: How Neurodegenerative Diseases Transform Art and Aesthetics
Exploring how neurodegenerative diseases affect aesthetic experience and creativity through the lens of neuroaesthetics
The Glutamate Key: How a Mexican Neuroscientist Is Revolutionizing Schizophrenia Treatment
Discover how Dr. Camilo de la Fuente-Sandoval's groundbreaking research on glutamate biomarkers is transforming schizophrenia treatment and personalizing psychiatric care.
Soft Touch, Sharp Mind: The PEDOT:PSS Hydrogels Revolutionizing Brain-Computer Interfaces
Explore how PEDOT:PSS hydrogels and DLP technology are creating revolutionary brain-computer interfaces that bridge the gap between rigid electronics and soft neural tissue.
Reading the Mind's Language: How AI Decodes Our Thoughts from Brain Signals
Explore how multimodal brain language decoding translates brain activity into text, offering new communication pathways for people with neurological conditions.
Deep Brain Stimulation: The 'Brain Pacemaker' Revolutionizing Neuroscience
Explore the revolutionary science of Deep Brain Stimulation (DBS), the brain pacemaker transforming treatment for Parkinson's, essential tremor, and psychiatric disorders.
Decoding the Brain's Control Room: New Interactive Map Reveals the Hypothalamus' Hidden Chemistry
Explore Chemopleth 1.0, the groundbreaking interactive spatial database mapping five neurochemical systems in the rat hypothalamus and zona incerta.
Decoding Movement from Brainwaves: How AI is Learning to Read Our Motions
Explore how machine learning algorithms decode EEG signals to identify physical motions, with applications in rehabilitation and human-computer interaction.